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Publikationen 2010

  1. Lötsch J, Klepstad P, Doehring A, and Dale O. A GTP cyclohydrolase 1 genetic variant delays cancer pain. Pain 2010 Jan;148(1):103-6
  2. Oertel BG, Felden L, Tran PV, Bradshaw MH, Angst MS, Schmidt H, Johnson S, Greer JJ, Geisslinger G, Varney MA, and Lötsch J. Selective antagonism of opioid-induced ventilatory depression by an ampakine molecule in humans without loss of opioid analgesia. Clin Pharmacol Ther 2010 Feb;87(2):204-11
  3. Hummel T and Lötsch J. Prognostic factors of olfactory dysfunction. Arch Otolaryngol Head Neck Surg. 2010 Apr;136(4):347-51
  4. Baum S, and Harder S. Appropriate dosing in patients with impaired renal function on medical wards before and after an educational intervention. Int J Clin Pharm Ther 2010 Jan;48(1):29-35
  5. Meyer dos Santos S, Klinkhardt U, Schneppenheim R, and Harder S. Using ImageJ for the quantitative analysis of flow-based adhesion assays in real-time under physiologic flow conditions. Platelets 2010 Feb;21(1):60-6
  6. Schmidtko A, Lötsch J, Freynhagen R, and Geisslinger G. Ziconotide for treatment of severe chronic pain. Lancet 2010 May 1;375(9725):1569-77
  7. Pierre S and Scholich K: Toponomics analysis in drug development. Molecular BioSystems 2010 Apr;6(4):641-7
  8. Lötsch J and Geisslinger G. Bedside-to-bench pharmacology: A complementary concept to translational pharmacology. Clin Pharmacol Ther 2010 Jun;87(6):647-9
  9. Lötsch J, Prüss H, Veh RW, and Doehring A. A KCNJ6 (Kir3.2, GIRK2) gene polymorphism modulates opioid effects on analgesia and addiction but not on pupil size. Pharmacogenet Genomics 2010 May;20(5):291-7
  10. Hummel T, Pfetzing U, and Lötsch J. A short olfactory test based on the identification of three odors. J Neurol 2010 Aug;257(8):1316-21
  11. Yasuo S, Koch M, Schmidt H, Ziebell S, Bojunga J, Geisslinger G, Korf HW. An endocannabinoid system is localized to the hypophysial pars tuberalis of Syrian hamsters and responds to photoperiodic changes. Cell Tissue Res 2010 Feb 18.
  12. Steinbrink SD, Pergola C, Bühring U, George S, Metzner J, Fischer AS, Häfner AK, Wisniewska JM, Geisslinger G, Werz O, Steinhilber D, Maier TJ. Sulindac sulfide suppresses 5-lipoxygenase at clinically relevant concentrations. Cell Mol Life Sci 2010 Mar;67(5):797-806.
  13. Rörsch F, Wobst I, Zettl H, Schubert-Zsilavecz M, Grösch S, Geisslinger G, Schneider G, Proschak E. Nonacidic inhibitors of human microsomal prostaglandin synthase 1 (mPGES 1) identified by a multistep virtual screening protocol. J Med Chem 2010 Jan 28;53(2):911-5
  14. Massa F, Mancini G, Schmidt H, Steindel F, Mackie K, Angioni C, Oliet S, Geisslinger G, Lutz B. Hippocampal dysregulation of the endocannabinoid system in diet-induced obese mice. J Neurosci 2010 May 5;30(18):6273-81
  15. Weigert A, Cremer S, Schmidt MV, von Knethen A, Angioni C, Geisslinger G, Brüne B. Cleavage of sphingosine kinase 2 by caspase-1 provokes its release from apoptotic cells. Blood 2010 Apr 29;115(17):3531-40
  16. Lötsch J and Geisslinger G. A critical appraisal of human genotyping for pain therapy. Trends Pharmacol Sci 2010 Jul;31(7):312-7
  17. Niederberger E and Geisslinger G. Analysis of NF-kappaB signaling pathways by proteomic approaches. Expert Rev Proteomics 2010 Apr;7(2):189-203
  18. Lötsch J, Freynhagen R, von Hentig N, Griessinger N, Zimmermann M, Sittl R, and Geisslinger G. Higher pain scores, similar opioid doses and side effects associated with antipyretic analgesics in specialised tertiary pain care. Inflamm Res 2010 Nov;59(11):989-95
  19. Doehring A, Hofmann WP, Schlecker C, Zeuzem S, Susser S, Geisslinger G, Sarrazin C, and Lötsch J. Screening for IL28B gene variants identifies predictors of hepatitis C therapy success. Antivir Ther 2010;15(8):1099-1106
  20. Bishay P, Schmidt H, Marian C, Häussler A, Wijnvoord N, Ziebell S, Metzner J, Koch M, Myrczek T, Bechmann I, Kuner R, Costigan M, Dehghani F, Geisslinger G, and Tegeder I. R-flurbiprofen reduces neuropathic pain in rodents by restoring endogenous cannabinoids. PLoS One. 2010 May 13;5(5):e10628.
  21. Claas RF, ter Braak M, Hegen B, Hardel V, Angioni C, Schmidt H, Jakobs KH, Van Veldhoven PP, zu Heringdorf DM. Enhanced Ca2+ storage in sphingosine-1-phosphate lyase-deficient fibroblasts. Cell Signal 2010 Mar;22(3):476-83
  22. Beissner F, Brandau A, Henke H, Felden F, Baumgärtner U, Treede R-D, Oertel BG, and Lötsch J. Quick discrimination of Adelta and C fiber mediated pain based on three verbal descriptors. PloS One 2010 Sep 23;5(9):e12944
  23. Schiffmann S, Ziebell S, Sandner J, Birod K, Deckmann K, Hartmann D, Rode S, Schmidt H, Angioni C, Geisslinger G, and Grösch S. Activation of ceramide synthase 6 by celecoxib leads to a selective induction of C(16:0)-ceramide. Biochem Pharmacol. 2010 Dec 1;80(11):1632-40
  24. Deckmann K, Rörsch F, Steri R, Schubert-Zsilavecz M, Geisslinger G, and Grösch S. Dimethylcelecoxib inhibits mPGES-1 promoter activity by influencing EGR1 and NF-kappaB. Biochem Pharmacol. 2010 Nov 1;80(9):1365-72
  25. Lötsch J and Tegeder I. Opioid-mediated drug actions cannot be concluded from naloxone induced reversal of anti-nociceptive effects in behavioural tests only. Eur J Pain 2010 Nov;14(10):981-4
  26. Wijnvoord N, Albuquerque B, Haussler A, Myrczek T, Popp L, and Tegeder I. Inter-strain differences of serotonergic inhibitory pain control in inbred mice. Mol Pain 2010 Oct 26;6(1):70
  27. Lange CM, Moradpour D, Doehring A, Lehr HA, Müllhaupt B, Bibert S, Bochud PY, Farnik H, Shi Y, Bechstein WO, Moench C, Hansmann ML, Sarrazin C, Lötsch J, Zeuzem S, Hofmann WP. Impact of donor and recipient IL28B genetic variations on hepatitis C virus liver graft reinfection. J Hepatol 2010 Dec 10. [Epub ahead of print