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Publikationen 2012

  1. Skarke C, Kuczka K, Tausch L, Werz O, Rossmanith T, Barrett JR, Harder S, Holtmeier W, Schwarz JA. Increased bioavailability of 11keto-ß-boswellic acid following single oral dose frankincense extract administration after a standardized meal in healthy male volunteers: Modeling and simulation considerations for evaluating drug exposures. J Clin Pharmacol 2012 (in press)
  2. Kallenborn-Gerhardt W, Lu R, Lorenz J, Gao W, Weiland J, Del Turco D, Deller T, Laube B, Betz H, Geisslinger G, Schmidtko A. Prolonged zymosan-induced inflammatory pain hypersensitivity in mice lacking glycine receptor alpha2. Behav Brain Res 2012 Jan 1;226(1):106-11
  3. Grösch S, Schiffmann S, Geisslinger G. Chain length-specific properties of ceramides. Prog Lipid Res 2012 Jan;51(1):50-62
  4. Wisniewska JM, Rodl CB, Kahnt AS, Buscato EL, Ulrich S, Tanrikulu Y, Achenbach J, Rörsch F, Grösch S, Schneider G, Cinatl J Jr, Proschak E, Steinhilber D and Hofmann B. Molecular characterization of EP6-A novel imidazo[1,2-a]pyridine based direct 5-lipoxygenase inhibitor. Biochem Pharmacol 2012 Jan 15;83(2):228-40
  5. Deckmann K, Rörsch F, Geisslinger G, Grösch S. Dimethylcelecoxib induces an inhibitory complex consisting of HDAC1/NF-kappaB(p65)RelA leading to transcriptional downregulation of mPGES-1 and EGR1. Cell Signal 2012 Feb;24(2):460-7
  6. Schiffmann S, Hartmann D, Fuchs S, Birod K, Ferreiros N, Schreiber Y, Zivkovic A, Geisslinger G, Grösch S, and Stark H. Inhibitors of specific ceramide synthases. Biochimie 2012 Feb;94(2):558-65
  7. Lötsch J, Walter C, Felden L, Preibisch C, Nöth U, Martin T, Anti S, Deichmann R, and Oertel BG. Extended cortical activations during evaluating successive pain stimuli. Soc Cogn Affect Neurosci 2012 Aug;7(6):698-707
  8. Lötsch J, Geisslinger G and Hummel T. Sniffing out pharmacology: Interactions of drugs with human olfaction. Trends Pharmacol Sci 2012 Apr;33(4):193-9
  9. Vermehren J, Lötsch J, Susser S, Wicker S, Berger A, Zeuzem S, Sarrazin C, and Doehring A. A common HLA-DPA1 variant is associated with hepatitis B virus infection but fails to distinguish active from inactive Caucasian carriers. PLoS One 2012;7(3):e32605
  10. Hartmann D, Lucks J, Fuchs S, Schiffmann S, Schreiber Y, Ferreiros N, Merkens J, Marschalek R, Geisslinger G and Grösch S.  Long chain ceramides and very long chain ceramides have opposite effects on human breast and colon cancer cell growth. Int J Biochem Cell Biol 2012 Jan 2. [Epub ahead of print]
  11. Deckmann K, Rörsch F, Geisslinger G and Grösch S. Identification of DNA-protein complexes using an improved, combined Western Blotting- Electrophoretic Mobility Shift Assay (WEMSA) with a fluorescence imaging system. Mol BioSyst 2012 (accepted)
  12. Harder S. Renal profiles of anticoagulants. J Clin Pharmacol 2012 Jul;52(7):964-75
  13. Tappe-Theodor A, Constantin CE, Tegeder I, Lechner SG, Langeslag M, Lepcynzsky P, Wirotanseng RI, Kurejova M, Agarwal N, Nagy G, Todd A, Wettschureck N, Offermanns S, Kress M, Lewin GR, Kuner R. Gα(q/11) signaling tonically modulates nociceptor function and contributes to activity-dependent sensitization. Pain 2012 Jan;153(1):184-96. Epub 2011 Nov 8.
  14. Oertel BG, Preibisch C, Martin T, Walter C, Gamer M, Deichmann R, and Lötsch J. Separating brain processing of pain from that of stimulus intensity. Hum Brain Mapp 2012 Apr;33(4):883-94
  15. Schlecker C, Ultsch A, Geisslinger G, and Lötsch J. The pharmacogenetic background of hepatitis C treatment. Mutation Research Reviews 2012 Mar 3. [Epub ahead of print]
  16. Kanngiesser M, Häussler A, Myrczek T, Küsener N, Lim HY, Geisslinger G, Niederberger E, and Tegeder I. Inhibitor kappa B kinase beta dependent cytokine upregulation in nociceptive neurons contributes to nociceptive hypersensitivity after sciatic nerve injury. J Pain 2012 May;13(5):485-97
  17. Luo C, Gangadharan V, Kumar Bali K, Agarwal N, Kurejova N, Tappe-Theodor A, Tegeder I, Feil S, Lewin G, Polgar E, Todd AJ, Schlossmann J, Hofmann F, Xie RG, Hu SJ, Feil R, Kuner T, Kuner R. Presynaptically localized cyclic GMP-dependent Protein Kinase 1 is a key determinant of spinal synaptic potentiation and pain hypersensitivity. PLoS Biol 2012 Mar;10(3):e1001283
  18. Lötsch J, Walter C, Felden L, Nöth U, Deichmann R, and Oertel BG. The human operculo-insular cortex is pain-preferentially but not pain-exclusively activated by trigeminal and olfactory stimuli. PLoS One 2012;7(4):e34798
  19. Müller M, Lötsch J, Giessmann T, Franke1 G, Walter R, Zschiesche M and Siegmund W. Relative bioavailability, pharmacodynamic effects in comparison with atropine and pharmacokinetic-pharmacodynamic correlations of methantheline in healthy subjects. Eur J Clin Pharmacol 2012 Apr 21
  20. Nollmann FI,  Dowling A, Kaiser M, Deckmann K, Grösch S, ffrench-Constant R and Bode HB. Synthesis of szentiamide, a depsipeptide from entomopathogenic Xenorhabdus szentirmaii with activity against Plasmodium falciparum. Beilstein J Org Chem 2012, 8, 528–533
  21. Schiffmann S, Ferreiros N,  Birod K, Eberle M, Schreiber Y, Pfeilschifter W, Ziemann U, Pierre S, Scholich K, Grösch S and  Geisslinger G. Ceramide synthase 6 plays a critical role in the development of experimental autoimmune encephalomyelitis. Journal of Immunology  2012 Jun 1;188(11):5723-33
  22. Kallenborn-Gerhardt W, Schröder K, Del Turco D, Lu R, Kynast K, Kosowski J, Niederberger E, Shah AM, Brandes  RP, Geisslinger G, Schmidtko A. NADPH oxidase-4 maintains neuropathic pain after peripheral nerve injury. J Neurosci 2012 (in press)
  23. Sisignano M, Park CK, Angioni C, Zhang DD, von Hehn C, Cobos EJ, Ghasemlou N, Xu ZZ, Kumaran V, Lu R, Grant A, Fischer MJ, Schmidtko A, Reeh P, Ji RR, Woolf CJ, Geisslinger G, Scholich K, Brenneis C. 5,6-EET Is Released upon Neuronal Activity and Induces Mechanical Pain Hypersensitivity via TRPA1 on Central Afferent Terminals. J Neurosci 2012 May 2;32(18):6364-6372
  24. Oertel BG, Vermehren J, Zimmermann M, Huynh TT, Doehring A, Ferreiros N, Senzel S, Schmitz-Rixen T, Erbe M, Geisslinger G, Harder S, Angst MS, and Lötsch J. Necessity and risks of arterial blood sampling in volunteer studies. Clin Pharmacokinet 2012 Oct;51(10):629-38
  25. Pickert G, Myrczek T, Rückert S, Weigert A, Häussler A, Ferreirós N, Brüne B, Lötsch J, Tegeder I. Inhibition of GTP cyclohydrolase reduces cancer pain in mice and enhances analgesic effects of morphine. J Mol Med (Berl). 2012 Jun 17. [Epub ahead of print]
  26. Coste O, Möser CV, Sisignano M, Kynast KL, Minden A, Geisslinger G, Niederberger E. The p21-activated kinase PAK 5 is involved in formalin-induced nociception through regulation of MAP-Kinase signaling and formalin-specific receptors. Behav Brain Res 2012 Jun 22. [Epub ahead of print]
  27. Oertel BG, Doehring A, Roskam B, Kettner M, Hackmann N, Ferreirós N, Schmidt PH, and Lötsch J. Genetic-epigenetic interaction modulates µ-opioid receptor regulation. Hum Mol Genet 2012 Aug 8. [Epub ahead of print]
  28. Schmidt-Kassow M, Schädle S, Otterbein S, Thiel C, Doehring A, Lötsch J, and Kaiser J. Kinetics of serum BDNF following low- versus high-intensity exercise in men and women. Neuroreport 2012 Oct 24;23(15):889-93
  29. Siebenhofer A, Ulrich LR, Mergenthal K, Roehl I, Rauck S, Berghold A, Harder S, Gerlach FM, Petersen JJ. Primary care management for optimized antithrombotic treatment [PICANT]: study protocol for a cluster-randomized controlled trial. Implement Sci. 2012 Aug 28;7(1):79. [Epub ahead of print]
  30. Tomasch M, Schwed SJ, Kuczka K, Meyer-dos-Santos S, Harder S, Nüsing RM, Paulke A, and Stark H. Fluorescent Human EP3 Receptor Antagonists. ACS Med Chem Lett August 8, 2012. DOI: 10.1021/ml300191g
  31. Oertel BG and Lötsch J. Clinical pharmacology of analgesics assessed with human experimental pain models: Bridging basic and clinical research. Br J Pharmacol 2012 Oct 19. doi: 10.1111/bph.12023. [Epub ahead of print]
  32. Lötsch J, Kraetsch HG, Wendler J, and Hummel T. Self-ratings of higher olfactory acuity contrast with reduced olfactory test results of fibromyalgia patients. Int J Psychophysiol 2012 Sep 15. pii: S0167-8760(12)00588-0. doi: 10.1016/j.ijpsycho.2012.09.003. [Epub ahead of print]
  33. Lempp T, Toennes SW, Wunder C, Russe OQ, Möser CV, Kynast KL, Freitag CM, Niederberger E. Altered gene expression in the prefrontal cortex of young rats induced by the ADHD drug atomoxetine. Prog Neuropsychopharmacol Biol Psychiatry. 2012 Aug 30. [Epub ahead of print]