Toggle navigation EN

Publikationen 2015

  1. Lötsch J, Dimova V, Hermens H, Zimmermann M, Geisslinger G, Oertel BG, and Ultsch A. Pattern of neuropathic pain induced by topical capsaicin application in healthy subjects. Pain 2015 Mar;156(3):405-14
  2. Lötsch J, Dimova V, and Oertel BG. Reply to "Can topical capsaicin induce a neuropathic pain?". Pain 2015 Jul;156(7):1369-70
  3. Abbas S, Ihle P, Harder S, Schubert I. Risk of hyperkalemia and combined us of spironolactone and long-term ACE inhibitor/angiotensin receptor blocker therapy in heart failure: a population- and insurance-based cohort in a real life setting. Pharmacoepidemiology and Drug Safety 2015 Feb 12
  4. Lötsch J, Daiker H, Hähner A, Ultsch A, and Hummel T. Drug-target based cross-sectional analysis of olfactory drug effects. Eur J Clin Pharmacol 2015 Apr;71(4):461-71
  5. Kringel D and Lötsch J. Pain research funding by the European Union Seventh Framework Programme. Eur J Pain 2015 May;19(5):595-600
  6. Lu R, Bausch AE, Kallenborn-Gerhardt W, Stoetzer C, Debruin N, Ruth P, Geisslinger G, Leffler A, Lukowski R, Schmidtko A. Slack channels expressed in sensory neurons control neuropathic pain in mice. J Neurosci 2015 Jan 21;35(3):1125-35
  7. Barthelmes J, Bazo AM, Pewzner-Jung Y, Schmitz K, Mayer CA, Foerch C, Eberle M, Tafferner N, Ferreirós N, Henke M, Geisslinger G, Futerman AH, Grösch S, and Schiffmann S. Lack of ceramide synthase 2 suppresses the development of experimental autoimmune encephalomyelitis by impairing the migratory capacity of neutrophils. Brain Behav Immun 2015 May;46:280-92
  8. Zhang DD, Linke B, Suo J, Zivkovic A, Schreiber Y, Ferreirós N, Henke M, Geisslinger G, Stark H, and Scholich K. Antinociceptive effects of FTY720 during trauma-induced neuropathic pain are mediated by spinal S1P receptors. Biol Chem 2015 Jun 1;396(6-7):783-94
  9. Meyer dos Santos S, Blankenbach K, Scholich K, Monsefi N, Keese M, Linke B, Deckmyn H, Nelson K, and Harder S. Platelets from flowing blood attach to the inflammatory chemokine CXCL16 expressed in the endothelium of the human vessel wall. Thrombosis and Hemostasis 2015 Apr 23;114(20150423)
  10. Thomas D, Herold N, Keppler OT, Geisslinger G, and Ferreirós N. Quantitation of endogenous nucleoside triphosphates and nucleosides in human cells by liquid chromatography tandem mass spectrometry. Anal Bioanal Chem 2015 May;407(13):3693-704
  11. Lötsch J, Dimova V, Lieb I, Zimmermann M, Oertel BG, and Ultsch A. Multimodal distribution of human cold pain thresholds. PLoS One 2015 May 20;10(5):e0125822
  12. Eberle M, Ebel P, Mayer CA, Barthelmes J, Tafferner N, Ferreiros N, Ulshöfer T, Henke M, Foerch C, de Bazo AM, Grösch S, Geisslinger G, Willecke K, Schiffmann S. Exacerbation of experimental autoimmune encephalomyelitis in ceramide synthase 6 knockout mice is associated with enhanced activation/migration of neutrophils. Immunol Cell Biol 2015 Apr 2. doi: 10.1038/icb.2015.47. [Epub ahead of print]
  13. Lötsch J, Reither N, Bogdanov V, Hähner A, Ultsch A, Hill K, and Hummel T. A brain-lesion pattern based algorithm for the diagnosis of post-traumatic olfactory loss. Rhinology 2015 Dec;53(4):365-70
  14. Schmitz K, Barthelmes J, Stolz L, Beyer S, Diehl O, and Tegeder I. Disease modifying diets and natural compounds for Multiple Sclerosis. Pharmacol Ther 2015 Apr;148:85-113
  15. Ultsch A and Lötsch J. Computed ABC analysis for rational selection of most informative variables in multivariate data. PLoS One 2015 Jun 10;10(6):e0129767
  16. Dimova V, Oertel BG, Kabakci G, Zimmermann M, Hermens H, Lautenbacher S, Ultsch A, and Lötsch J. A more pessimistic life-orientation is associated with experimental inducibility of neuropathy-like pain pattern in healthy subjects. J Pain 2015 Jun 5
  17. Dahan A, and Lötsch J. Morphine is not a prodrug. Br J Anaesth 2015 Jun;114(6):1005-6
  18. Möser CV, Stephan H, Altenrath K, Kynast KL, Russe OQ, Olbrich K, Geisslinger G, and Niederberger E. TANK-binding kinase 1 (TBK1) modulates inflammatory hyperalgesia by regulating MAP kinases and NF-κB dependent genes. J Neuroinflammation 2015 May 23;12(1):100.
  19. Weth D, Benetti C, Rauch C, Gstraunthaler G, Schmidt H, Geisslinger G, Sabbadini R, Proia RL, and Kress M. Activated platelets release sphingosine 1-phosphate and induce hypersensitivity to noxious heat stimuli in vivo. Front Neurosci 2015 Apr 22;9:140
  20. Olesch C, Sha W, Angioni C, Sha LK, Açaf E, Patrignani P, Jakobsson PJ, Radeke HH, Grösch S, Geisslinger G, von Knethen A, Weigert A, and Brüne B. MPGES-1-derived PGE2 suppresses CD80 expression on tumor-associated phagocytes to inhibit anti-tumor immune responses in breast cancer. Oncotarget 2015 Apr 30;6(12):10284-96
  21. Koch M, Ferreirós N, Geisslinger G, Dehghani F, and Korf HW. Rhythmic control of endocannabinoids in the rat pineal gland. Chronobiol Int 2015 Jun 10:1-6
  22. King TS, Russe OQ, Möser CV, Ferreirós N, Kynast KL, Knothe C, Olbrich K, Geisslinger G, and Niederberger E. AMP-activated protein kinase Is activated by non-steroidal anti-inflammatory drugs. Eur J Pharmacol 2015 Jun 3
  23. Walter C, Dimova V, Bu J, Parnham MJ, Oertel BG, and Lötsch J. Inverted perceptual judgment of nociceptive stimuli at threshold level following inconsistent cues. PLoS One 2015 Jul 6;10(7):e0132069
  24. Lötsch J, Knothe C, Lippmann C, Ultsch A, Hummel T, and Walter C. Olfactory drug effects approached from human-derived data. Drug Discov Today 2015 Jul 6. pii: S1359-6446(15)00259-7
  25. Latremoliere A, Latini A, Andrews N, Cronin SJ, Fujita M, Gorska K, Hovius R, Romero C, Chuaiphichai S, Painter M, Miracca G, Babaniyi O, Remor AP, Duong K, Riva P, Barrett LB, Ferreirós N, Naylor A, Penninger JM, Tegeder I, Zhong J, Blagg J, Channon KM, Johnsson K, Costigan M, Woolf CJ. Reduction of Neuropathic and Inflammatory Pain through Inhibition of the Tetrahydrobiopterin Pathway. Neuron 2015 Jun 17;86(6):1393-406
  26. Niederberger E, King TS, Russe OQ, and Geisslinger G. Activation of AMPK and its Impact on Exercise Capacity. Sports Med 2015 Jul 18. [Epub ahead of print]
  27. Syhr KM, Oertel BG, and Geisslinger G. Drug interactions in pain therapy. Schmerz 2015 Jul 3. [Epub ahead of print]
  28. Knothe C, Doehring A, Ultsch A, and Lötsch J. Methadone induces hypermethylation of human DNA. Epigenomics 2015 Sep 4. [Epub ahead of print]
  29. Namgaladze D, Snodgrass RG, Angioni C, Grossmann N, Dehne N, Geisslinger G, and Brüne B. AMP-activated Protein Kinase Suppresses Arachidonate 15-Lipoxygenase Expression in Interleukin-4-polarized Human Macrophages. J Biol Chem 2015 Aug 14. [Epub ahead of print]
  30. Niederberger E, Kuner R, and Geißlinger G. Pharmacological aspects of pain research in Germany. Schmerz 2015 Aug 21
  31. Lehmann C, Homann J, Ball AK, Blöcher R, Kleinschmidt TK, Basavarajappa D, Angioni C, Ferreirós N, Häfner AK, Rådmark O, Proschak E, Haeggström JZ, Geisslinger G, Parnham MJ, Steinhilber D, Kahnt AS. Lipoxin and resolvin biosynthesis is dependent on 5-lipoxygenase activating protein. FASEB J 2015 Aug 19. pii: fj.15-275487
  32. Lötsch J, Niederberger E, and Ultsch A. Computational functional genomics based analysis of pain-relevant micro-RNAs. Human Genet 2015 Sep 18. [Epub ahead of print]
  33. Lötsch J, Dimova V, Ultsch A, Lieb I, Zimmermann M, Geisslinger G, and Oertel BG. A small yet comprehensive subset of human experimental pain models emerging from correlation analysis with a clinical quantitative sensory testing protocol in healthy subjects. Eur J Pain 2015 Oct 22. doi: 10.1002/ejp.803. [Epub ahead of print]
  34. Dimova V, Lötsch J, Hühne K, Winterpacht A, Heesen M, Parthum A, Weber PG, Carbon R, Griessinger N, Sittl R, and Lautenbacher S. Association of genetic and psychological factors with persistent pain after cosmetic thoracic surgery. J Pain Res 2015 Nov 27;8:829-844
  35. Moll J, Meyer dos Santos S, Hils B, Dornuf F, Rodrigues Meyer dos Santos I, Singer OC, Ferreirós N, Labocha S, Blücher A, Harder S, and Krozer V. Micro-optical prototyping of a surface acoustic wave-based point-of-care coagulation assay and first application in anticoagulated patients. Int J Clin Pharm Ther 2015 (accepted)
  36. Walter C, Oertel BG, Felden L, Kell CA, Nöth U, Vermehren J, Kaiser J, Deichmann R, and Lötsch J. Brain mapping-based model of Δ9-tetrahydrocannabinol effects on connectivity in the pain matrix. Neuropsychopharmacol 2015 Oct 30. doi: 10.1038/npp.2015.336. [Epub ahead of print]
  37. Ultsch A, Thrun MC, Hansen-Goos O, and Lötsch J. Identification of molecular fingerprints in human heat pain thresholds by use of an interactive mixture model R toolbox (AdaptGauss). Int J Mol Sci 2015 Oct 28;16(10):25897-25911.
  38. King-Himmelreich TS, Möser CV,  Wolters M, Olbrich K, Geisslinger G, and Niederberger E. Age-Dependent Changes in the Inflammatory Nociceptive Behavior in Mice. Int J Mol Sci 2015 (accepted)
  39. González O, Ferreirós N, Blanco ME, and Alonso RM. Cardiovascular drug determination in bioanalysis: an update. Bioanalysis 2015 Sep 23 [Epub ahead of print]
  40. Grammatikos G, Ferreirós N, Waidmann O, Bon D, Schroeter S, Koch A, Herrmann E, Zeuzem S, Kronenberger B, Pfeilschifter J. Serum Sphingolipid Variations Associate with Hepatic Decompensation and Survival in Patients with Cirrhosis. PLoS One 2015 Sep 18;10(9):e0138130
  41. Lacroix A, Toussay X, Anenberg E, Lecrux C, Ferreirós N, Karagiannis A, Plaisier F, Chausson P, Jarlier F, Burgess SA, Hillman EM, Tegeder I, Murphy TH, Hamel E, and Cauli B. COX-2-Derived Prostaglandin E2 Produced by Pyramidal Neurons Contributes to Neurovascular Coupling in the Rodent Cerebral Cortex. J Neurosci 2015 Aug 26;35(34):11791-810
  42. Schmitz K, Mangels N, Häussler A, Ferreirós N, Fleming I, and Tegeder I. Pro-inflammatory obesity in aged cannabinoid-2 receptor-deficient mice. Int J Obes (Lond) 2015 Aug 25. doi: 10.1038/ijo.2015.169 [Epub ahead of print]
  43. Beyer S, Moosmann A, Kahnt AS, Ulshöfer T, Parnham MJ, Ferreirós N, Wagner S, and Wacker MG. Drug Release and Targeting: the Versatility of Polymethacrylate Nanoparticles for Peroral Administration Revealed by Using an Optimized In Vitro-Toolbox. Pharm Res 2015 Dec;32(12):3986-98
  44. Knape T, Flesch D, Kuchler L, Sha LK, Giegerich AK, Labocha S, Ferreirós N, Schmid T, Wurglics M, Schubert-Zsilavecz M, Proschak E, Brüne B, Parnham MJ, and von Knethen A. Identification and characterisation of a prototype for a new class of competitive PPARγ antagonists. Eur J Pharmacol 2015 May 15;755:16-26
  45. Grammatikos G, Ferreiros N, Bon D, Schwalm S, Dietz J, Berkowski C, Fitting D, Herrmann E, Zeuzem S, Sarrazin C, and Pfeilschifter J. Variations in serum sphingolipid levels associate with liver fibrosis progression and poor treatment outcome in hepatitis C virus but not hepatitis B virus infection. Hepatology. 2015 Mar;61(3):812-22
  46. Farnik H, Zimmermann T, Herrmann E, Bechstein WO, Kronenberger B, Galle PR, Labocha S, Ferreiros N, Geisslinger G, Zeuzem S, Sarrazin C, and Welker MW. Telaprevir drug monitoring during antiviral therapy of hepatitis C graft infection after liver transplantation. Liver Int 2015 Jan;35(1):176-83
  47. Schröder M, Arlt O, Schmidt H, Huwiler A, Angioni C, Pfeilschifter JM, Schwiebs A, and Radeke HH. Subcellular distribution of FTY720 and FTY720-phosphate in immune cells - another aspect of Fingolimod action relevant for therapeutic application. Biol Chem 2015 Jun;396(6-7):795-802
  48. Tafferner N, Barthelmes J, Eberle M, Ulshöfer T, Henke M, deBruin N, Mayer CA, Foerch C, Geisslinger G, Parnham MJ, and Schiffmann S. Alpha-methylacyl-CoA racemase deletion has mutually counteracting effects on T-cell responses, associated with unchanged course of EAE. Eur J Immunol 2015 Dec 9 [Epub ahead of print]
  49. Dörr A, Pierre S, Zhang DD, Henke M, Holland S, and Scholich K. MYCBP2 Is a Guanosine Exchange Factor for Ran Protein and Determines Its Localization in Neurons of Dorsal Root Ganglia. J Biol Chem 2015 Oct 16;290(42):25620-35
  50. Ahmetaj-Shala B, Kirkby NS, Knowles R, Al'Yamani M, Mazi S, Wang Z, Tucker AT, Mackenzie L, Armstrong PC, Nüsing RM, Tomlinson JA, Warner TD, Leiper J, Mitchell JA. Evidence that links loss of cyclooxygenase-2 with increased asymmetric dimethylarginine: novel explanation of cardiovascular side effects associated with anti-inflammatory drugs. Circulation 2015 Feb 17;131(7):633-42
  51. Valek L, Kanngießer M, Häussler A, Agarwal N, Lillig CH, and Tegeder I. Redoxins in peripheral neurons after sciatic nerve injury. Free Radic Biol Med 2015 Oct 9;89:581-592
  52. Valek L, Kanngießer M,  and Tegeder I. Expression and regulation of redoxins at nociceptive signaling sites after sciatic nerve injury in mice. DiB 5 2015 834–845. doi:10.1016/j.dib.2015.10.038
  53. Vogt J, Yang JW, Cheng Y, Li Y, Liu X, Baumgart J, Thalman C, Kirischuk S, Unichenko P, Horta G, Radyushkin K, Stroh A, Richers S, Sahragard N, Distler U, Tenzer S, Qiao L, Ferreiros N, Tegeder I, Morris AJ, Luhmann HJ, Huai J, and Nitsch R. Molecular cause and functional impact of altered synaptic lipid signaling due to a SNP in the prg-1 gene. Embo Mol Med 2015 (accepted)