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Publikationen 2018

  1. Lötsch J and Ultsch A. Machine learning in pain research. Pain 2018 Apr;159(4):623-630
  2. Lötsch J and Kringel D. Use of computational functional genomics in drug discovery and repurposing for analgesic indications Clin Pharmacol Ther 2018 Jan 19. doi: 10.1002/cpt.960. [Epub ahead of print]
  3. Tunaru S, Bonavion R, Brandenburger I, Preussner J, Thomas D, Scholich K, and Offermanns S. 20-HETE promotes glucose-stimulated insulin secretion in an autocrine manner through FFAR1 Nat Comm 2018 Jan 12;9(1):177
  4. Mertens C, Mora J, Ören B, Grein S, Winslow S, Scholich K, Weigert A, Malmström P, Forsare C, Fernö M, Schmid T, Brüne B, and Jung M. Macrophage-derived lipocalin-2 transports iron in the tumor microenvironment. Oncoimmunology 2017 Dec 22;7(3):e1408751. doi: 10.1080/2162402X.2017.1408751. eCollection 2018
  5. Muth C, Uhlmann L, Haefeli WE, Rochon J, van den Akker M, Perera R, Güthlin C, Beyer M, Oswald F, Valderas JM, Knottnerus A, Gerlach FM, and Harder S. Effectiveness of a complex intervention on PRIoritising MUltimedication in Multimorbidity (PRIMUM) in primary care: results of a pragmatic cluster- randomised controlled trial. BMJ open 2018 Feb 24;8(2):e017740
  6. Weyer-Menkhoff I, Thrun MC, and Lötsch J. Machine-learned analysis of quantitative sensory testing re-sponses to noxious cold stimulation in healthy subjects. Eur J Pain 2018 May;22(5):862-874
  7. Kessel J, Dolff B, Wichelhaus T, Keiner N, Hogardt M, Reinheimer C, Wieters I, Harder S, Kempf VAJ, and Stephan C. Piperacillin/Tazobactam Shortage: Central Restriction and Alternative Recommendations as Effective Antibiotic-Stewardship Intervention at a Maximal Care Hospital. Dtsch Med Wochenschr 2018 Apr;143(8):e59-e67
  8. Wegner MS, Gruber L, Mattjus P, Geisslinger G, and Grösch S. The UDP-glucose ceramide glycosyltransferase (UGCG) and the link to multidrug resistance protein 1 (MDR1). BMC Cancer 2018 Feb 6;18(1):153
  9. Vollert J, Magerl W, Baron R, Binder A, Enax-Krumova EK, Geisslinger G, Gierthmühlen J, Henrich F, Hüllemann P, Klein T, Lötsch J, Maier C, Oertel BG, Schuh-Hofer S, Tölle TR, and Treede RD. Pathophysiological mechanisms of neuropathic pain: comparison of sensory phenotypes in patients and human surrogate pain models. Pain 2018 Feb 24. doi: 10.1097/j.pain.0000000000001190. [Epub ahead of print]
  10. Kringel D, Geisslinger G, Resch E, Oertel BG, Thrun MC, Heinemann S, and Lötsch J. Machine-learned analysis of the association of next-generation sequencing based human TRPV1 and TRPA1 genotypes with the sensitivity to heat stimuli and topically applied capsaicin. Pain 2018 Mar 27. doi: 10.1097/j.pain.0000000000001222. [Epub ahead of print]
  11. Grösch S, Alessenko AV, and Albi E. The Many Facets of Sphingolipids in the Specific Phases of Acute Inflammatory Response. Mediators Inflamm 2018 Feb 6;2018:5378284
  12. Zimmer B, Angioni C, Osthues T, Toewe A, Thomas D, Pierre SC, Geisslinger G, Scholich K and Sisignano M. The oxidized linoleic acid metabolite 12,13-DiHOME mediates thermal hyperalgesia during inflammatory pain. BBA Molecular and Cell Biology of Lipids 2018 Apr 4;1863(7):669-678
  13. Lötsch J, Lerch F, Djaldetti R, Tegeder I, and Ultsch A. Identification of disease-distinct complex biomarker patterns by means of unsupervised machine-learning using an interactive R toolbox (Umatrix). BMC Big Data Analytics 2018 Nov;121(5):1123-1132
  14. Lötsch J, Sipilä R, Dimova V, and Kalso E. Machine-learned selection of psychological questionnaire items relevant to the development of persistent pain after breast cancer surgery. Br J Anaesth 2018 Nov;121(5):1123-1132
  15. Lippmann C, Kringel D, Ultsch A, and Lötsch J. Computational functional genomics-based approaches in analgesic drug discovery and repurposing. Pharmacogenomics 2018 May 24. doi: 10.2217/pgs-2018-0036. [Epub ahead of print]
  16. Thalman C, Horta G, Qiao L, Endle H, Tegeder I, Cheng H, Laube G, Sigrudsson T, Hauser MJ, Tenzer S, Distler U, Aoki J, Morris AJ, Geisslinger G, Röper J, Kirischuk S, Luhmann HJ, Radyushkin K, Nitsch R, and Vogt J. Synaptic phospholipids as a new target for cortical hyperexcitability and E/I balance in psychiatric disorders. Mol Psychiatry 2018 May 9. doi: 10.1038/s41380-018-0053-1. [Epub ahead of print]
  17. Lötsch J, Sipilä R, Tasmuth T, Kringel D, Estlander A-M, Meretoja T, Kalso E, and Ultsch A. Machine-learning-derived classifier predicts absence of persistent pain after breast cancer surgery with high accuracy. Breast Cancer Res Ther 2018 Jun 6. doi: 10.1007/s10549-018-4841-8. [Epub ahead of print]
  18. Albi E, Alessenko A, and Grösch S. Sphingolipids in inflammation. Mediators Inflamm 2018 May 6
  19. Kringel D, Lippmann C, Parnham MJ, Kalso E, Ultsch A, and Lötsch J. A machine-learned analysis of human gene polymorphisms modulating persisting pain points to major roles of neuroimmune processes. Eur J Pain 2018 Nov;22(10):1735-1756
  20. Weyer-Menkhoff I and Lötsch J. Human pharmacological approaches to TRP-ion-channel-based analgesic drug development. Drug Discovery Today 2018 Jun 30. pii: S1359-6446(18)30154-5
  21. Ujeyl M, Köster I, Wille H, Stammschulte T, Hein R, Harder S, Gundert-Remy U, Bleek J, Ihle P, Schröder H, Schillinger G, Zawinell A, and Schubert I. Comparative risks of bleeding, ischemic stroke and mortality with direct oral anticoagulants versus phenprocoumon in patients with atrial fibrillation. Eur J Clin Pharmacol 2018 Jun 16. doi: 10.1007/s00228-018-2504-7
  22. Harder S, Meyer dos Santos S, Krozer V, and Moll J. Surface acoustic wave-based microfluidic coagulation device for monitoring anticoagulant therapy. Seminars in Thrombosis and Hemostasis 2018 (accepted)
  23. Brachtendorf S, Wanger RA, Birod K, Thomas D, Trautmann S, Wegner MS, Fuhrmann DC, Brüne B, Geisslinger G, and Grösch S. Chemosensitivity of human colon cancer cells is influenced by a p53-dependent enhancement of ceramide synthase 5 and induction of autophagy. Biochim Biophys Acta 2018 Jul 27. pii: S1388-1981(18)30181-1
  24. Wegner MS, Schömel N, Gruber L, Örtel SB, Kjellberg MA, Mattjus P, Kurz J, Trautmann S, Peng B, Wegner M, Kaulich M, Ahrends R, Geisslinger G, and Grösch S. UDP-glucose ceramide glucosyltransferase activates AKT, promoted proliferation, and doxorubicin resistance in breast cancer cells. Cell Mol Life Sci 2018 Mar 17
  25. Kringel D, Kaunisto M, Lippmann C, Kalso E, and Lötsch J. Development of an AmpliSeqTM Panel for Next-Generation Sequencing of a Set of Genetic Predictors of Persisting Pain. Frontiers Pharmacol 2018 Sep 19;9:1008. doi: 10.3389/fphar.2018.01008. eCollection 2018
  26. Annak O, Heidegger T, Walter C, Deichmann R, Nöth U, Hansen-Goos O, Ziemann U, and Lötsch J. Effects of continuous theta-burst stimulation of the primary motor and secondary somatosensory areas on the central processing and the perception of tri-geminal nociceptive input in healthy volunteers. Pain 2018 Sep 7. doi: 10.1097/j.pain.0000000000001393. [Epub ahead of print]
  27. Lötsch J, Schiffmann S, Schmitz K, Brunkhorst R, Lerch F, Ferreiros N, Wicker S, Tegeder I, Geisslinger G, and Ultsch A. Machine-learning based lipid mediator serum concentration patterns allow identification of multiple sclerosis patients with high accuracy. Sci Rep 2018 Oct 5;8(1):14884
  28. Lötsch J, Kringel D, and Hummel T. Machine learning in human olfactory research. Chem Sens 2018 (accepted)
  29. Riess H, Prandoni P, Harder S, Kreher S, Bauersachs R. Direct oral anticoagulants for the treatment of venous thromboembolism in cancer patients: potential for drug–drug interactions. Critical Reviews in Oncology / Hematology 132 (2018) 169–179
  30. Kern K, Schäfer SMG, Cohnen J, Pierre S, Osthues T, Tarighi N, Hohmann S, Ferreiros N, Brüne B, Weigert A, Geisslinger G, Sisignano M, and Scholich K. The G2A Receptor Controls Polarization of Macrophage by Determining Their Localization Within the Inflamed Tissue. Front Immunol. 2018 Oct 1;9:2261
  31. Knecht KM, Buzovetsky O, Schneider C, Thomas D, Srikanth V, Kaderali L, Tofoleanu F, Reiss K, Ferreirós N, Geisslinger G, Batista VS, Ji X, Cinatl J Jr, Keppler OT, and Xiong Y. The structural basis for cancer drug interactions with the catalytic and allosteric sites of SAMHD1. Proc Natl Acad Sci U S A. 2018 Oct 10
  32. Kurz J, Brunkhorst R, Foerch C, Blum L, Henke M, Gabriel L, Ulshöfer T, Ferreirós N, Parnham MJ, Geisslinger G, and Schiffmann S. The relevance of ceramides and their synthesizing enzymes for multiple sclerosis. Clin Sci (Lond). 2018 Aug 17;132(17):1963-1976
  33. Snodgrass RG, Zezina E, Namgaladze D, Gupta S, Angioni C, Geisslinger G, Lütjohann D, and Brüne B. A Novel Function for 15-Lipoxygenases in Cholesterol Homeostasis and CCL17 Production in Human Macrophages. Front Immunol. 2018 Aug 24;9:1906
  34. Fettel J, Kühn B, Guillen NA, Sürün D, Peters M, Bauer R, Angioni C, Geisslinger G, Schnütgen F, Meyer Zu Heringdorf D, Werz O, Meybohm P, Zacharowski K, Steinhilber D, Roos J, and Maier TJ. Sphingosine-1-phosphate (S1P) induces potent anti-inflammatory effects in vitro and in vivo by S1P receptor 4-mediated suppression of 5-lipoxygenase activity. FASEB J. 2018 Sep 6:fj201800221R
  35. Blum L, Tafferner N, Spring I, Kurz J, deBruin N, Geisslinger G, Parnham MJ, Schiffmann S. Dietary phytol reduces clinical symptoms in experimental autoimmune encephalomyelitis (EAE) at least partially by modulating NOX2 expression. J Mol Med (Berl). 2018 Oct;96(10):1131-1144
  36. Toewe A, Balas L, Durand T, Geisslinger G, and Ferreirós N. Simultaneous determination of PUFA-derived pro-resolving metabolites and pathway markers using chiral chromatography and tandem mass spectrometry. Anal Chim Acta. 2018 Nov 15;1031:185-194
  37. Vasconez AE, Janetzko P, Oo JA, Pflüger-Müller B, Ratiu C, Gu L, Helin K, Geisslinger G, Fleming I, Schröder K, Fork C, Brandes RP, and Leisegang MS. The histone demethylase Jarid1b mediates angiotensin II-induced endothelial dysfunction by controlling the 3'UTR of soluble epoxide hydrolase. Acta Physiol (Oxf). 2018 Aug 4:e13168
  38. Shiratori H, Feinweber C, Luckhardt S, Wallner N, Geisslinger G, Weigert A, and Parnham MJ. An in vitro test system for compounds that modulate human inflammatory macrophage polarization. Eur J Pharmacol. 2018 Aug 15;833:328-338
  39. Hitzel J, Lee E, Zhang Y, Bibli SI, Li X, Zukunft S, Pflüger B, Hu J, Schürmann C, Vasconez AE, Oo JA, Kratzer A, Kumar S, Rezende F, Josipovic I, Thomas D, Giral H, Schreiber Y, Geisslinger G, Fork C, Yang X, Sigala F, Romanoski CE, Kroll J, Jo H, Landmesser U, Lusis AJ, Namgaladze D, Fleming I, Leisegang MS, Zhu J, and Brandes RP. Oxidized phospholipids regulate amino acid metabolism through MTHFD2 to facilitate nucleotide release in endothelial cells. Nat Commun. 2018 Jun 12;9(1):2292
  40. Schierle S, Flauaus C, Heitel P, Willems S, Schmidt J, Kaiser A, Weizel L, Goebel T, Kahnt AS, Geisslinger G, Steinhilber D, Wurglics M, Rovati GE, Schmidtko A, Proschak E, and Merk D. Boosting Anti-Inflammatory Potency of Zafirlukast by Designed Polypharmacology. J Med Chem. 2018 Jul 12;61(13):5758-5764
  41. Treutlein EM, Kern K, Weigert A, Tarighi N, Schuh CD, Nüsing RM, Schreiber Y, Ferreirós N, Brüne B, Geisslinger G, Pierre S, and Scholich K. The prostaglandin E2 receptor EP3 controls CC-chemokine ligand 2-mediated neuropathic pain induced by mechanical nerve damage. J Biol Chem. 2018 Jun 22;293(25):9685-9695
  42. Hofmann MCJ, Schmidt M, Arne O, Geisslinger G, Parnham MJ, and de Bruin NMWJ. Non-invasive bioluminescence imaging as a standardized assessment measure in mouse models of dermal inflammation. J Dermatol Sci. 2018 Apr 23. pii: S0923-1811(18)30187-7
  43. Giller K, Drews B, Berard J, Kienberger H, Schmicke M, Frank J, Spanier B, Daniel H, Geisslinger G, and Ulbrich SE. Bovine embryo elongation is altered due to maternal fatty acid supplementation. Biol Reprod. 2018 Sep 1;99(3):600-610
  44. Zimmer B, Angioni C, Osthues T, Toewe A, Thomas D, Pierre SC, Geisslinger G, Scholich K, and Sisignano M. The oxidized linoleic acid metabolite 12,13-DiHOME mediates thermal hyperalgesia during inflammatory pain. Biochim Biophys Acta Mol Cell Biol Lipids. 2018 Jul;1863(7):669-678