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Publikationen 2020

  1. Lötsch J and Ultsch A. Current projection methods-induced biases at subgroup detection for machine-learning based data-analysis of biomedical data. Int J Mol Sci 2020 (accepted)
  2. Lerch F, Ultsch A, and Lötsch J. Distribution Optimization: An evolutionary algorithm to separate Gaussian mixtures. Sci Reports 2020 Jan 20;10(1):648
  3. Klitsch A, Evdokimov D, Frank J, Thomas D, Saffer N, Meyer Zu Altenschildesche C, Sisignano M, Kampik D, Malik RA, Sommer C, and   Üceyler N. Reduced association between dendritic cells and corneal sub-basal nerve fibers in patients with fibromyalgia syndrome. J Perip Nerv Syst 2019 Dec 17. doi: 10.1111/jns.12360
  4. Schäfer SMG, Sendetski M, Angioni, C, Nüsing RM, Geisslinger G, Scholich K, and Sisignano M. The omega-3 lipid 17,18-EEQ sensitizes TRPV1 and TRPA1 in sensory neurons through the prostacyclin receptor (IP). Neuropharmacology 2020 accepted
  5. Karathanasis C, Medler J, Fricke F, Smith S, Malkusch S, Widera D, Fulda S, Wajant H, van Wijk SJL, Dikic I, and Heilemann M. Single-molecule imaging reveals the oligomeric state of functional TNFalpha-induced plasma membrane TNFR1 clusters in cells. Science Signaling 14 Jan 2020: Vol. 13, Issue 614, eaax5647, DOI: 10.1126/scisignal.aax5647
  6. Sipilä R, Kalso E, and Lötsch J. Machine-learned identification of psychological subgroups with relation to pain interference in patients after breast cancer treatments. The Breast 2020 (accepted)
  7. Ultsch A, and Lötsch J. The Fundamental Clustering and Projection Suite (FCPS): A data set collection to test the performance of clustering and data projection algorithms. Data 2020 (accepted)
  8. Weinelt N, Karathanasis C, Smith S, Medler J, Malkusch S, Fulda S, Wajant H, Heilemann M, and van Wijk, SJL. Quantitative single-molecule imaging of TNFR1 reveals zafirlukast as antagonist of TNFR1 clustering and TNFalpha induced NFkappaB signaling. J Leucocyte Biol 2020
  9. Fischer C, Endle H, Schumann L, Wilken-Schmitz A, Kaiser J, Gerber S, Vogelaar CF, Schmidt MHH, Nitsch R, Snodgrass I, Thomas D, Vogt J, and Tegeder I. Prevention of age-associated neuronal hyperexcitability with improved learning and attention upon knockout or antagonism of LPAR2. Cell Mol Life Sci 2020 (accepted)
  10. Klatt-Schreiner K, Valek L, Kang JS, Khlebtovsky A, Trautmann S, Hahnefeld L, Schreiber Y, Gurke R, Thomas D, Wilken-Schmitz A, Wicker S, Auburger G, Geisslinger G, Lötsch J, Pfeilschifter W, Djaldetti R, and Tegeder I. High glucosylceramides and low anandamide contribute to sensory loss and pain in Parkinson's Disease. Movement Disorder 2020 (accepted)
  11. Lötsch J, Kringel D, Geisslinger G, Oertel BG, Resch E, and Malkusch S. Machine-learned association of next-generation sequencing derivedvariants in thermosensitive ion channels genes with human thermal pain-sensitivity phenotypes. Int J Mol Sci 2020 (accepted)
  12. El-Hindi K, Brachtendorf S, Hartel JC, Oertel S, Birod K, Trautmann S, Thomas D, Ulshöfer T, Weigert A, Utermöhlen O, Krönke M, and Grösch S. CerS5 deficiency aggravates DSS-induced colitis and colon carcinogenesis and impairs T-cell activation. Cancers 2020 (accepted)
  13. Sisignano M, Steinhilber, D, Parnham MJ, and Geisslinger G Exploring CYP2J2 - lipid synthesis, inhibitors and therapeutic implications. Drug Discovery Today 2020 (accepted)
  14. Miettinen T, Mäntyselkä P, Hagelberg N, Mustola S, Kalso E, and Lötsch J. Machine learning suggests sleep as a core factor in chronic pain. Pain 2020 (accepted)
  15. Gross T, Wack G, Syhr KMJ, Tolmachova T, Seabra MC, Geisslinger G, Niederberger E, Schmidtko A and Kallenborn-Gerhardt W. Rab27a Contributes to the Processing of Inflammatory Pain in Mice. Cells 2020, 9(6), 1488; doi:10.3390/cells9061488
  16. Möller M, Wasel J, Schmetzer J, Weiß U, Meissner M, Schiffmann S, Weigert A, Möser CV, and Niederberger E. The Specific IKKepsilon/TBK1 Inhibitor Amlexanox Suppresses Human Melanoma by the Inhibition of Autophagy, NFkappaB and MAP Kinase Pathways. Int J Mol Sci 2020, 21(13), 4721; doi:10.3390/ijms21134721
  17. Osthues T, Zimmer B, Rimola V, Klann K, Schilling K, Mathoor P, Angioni C, Weigert A, Geisslinger G, Münch C, Scholich K, and Sisignano M. The lipid receptor G2A (GPR132) mediates macrophage migration in nerve-injury induced neuropathic pain. Cells 2020 (accepted)
  18. Lötsch J, Oertel BG, Felden L, Noeth U, Deichmann R, Hummel T, and Walter C. Central encoding of the strength of intranasal chemosensory trigeminal stimuli in a human experimental pain setting. Human Brain Mapping 2020 (accepted)
  19. Lötsch J, and Ultsch A. A non-parametric effect-size measure capturing changes in central tendency and data distribution shape. PLoS One 2020 (accepted)
  20. Wolters MC, Schmetzer J, Möser CV, Hahnefeld L, Angioni C, Thomas D, Ferreirós N, Geisslinger G, and Niederberger E. Exercise-Induced Changes in Bioactive Lipids Might Serve as Potential Predictors of Post-Exercise Hypotension. A Pilot Study in Healthy Volunteers. Cells 2020, 9(9):E2111. doi: 10.3390/cells9092111
  21. Niederberger E. Novel Insights into Molecular Mechanisms of Chronic Pain. Cells 2020, 9(10):E2220. doi: 10.3390/cells9102220
  22. Rimola V, Hahnefeld L, Zhao J, Jiang C, Angioni C, Schreiber Y, Osthues T, Pierre S, Geisslinger G, Ji RR, Scholich K, and Sisignano M. Lysophospholipids contribute to oxaliplatin-induced acute peripheral pain. J Neurosci 2020 (accepted)
  23. Lötsch J and Malkusch S. Interpretation of cluster structures in pain-related phenotype data using explainable artificial intelligence (XAI). Eur J Pain 2020 (accepted)
  24. Lütjohann D, Stellaard F, Kerksiek A, Lötsch J, and Oertel BG. Serum 4beta-hydroxycholesterol increases during fluconazole treatment. Eur J Clin Pharmacol 2020 (accepted)