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Publikationen 2021

  1. Weiss U, Möller M, Husseini SA, Manderscheid C, Häusler J, Geisslinger G, and Niederberger E. Inhibition of HDAC Enzymes Contributes to Differential Expression of Pro-Inflammatory Proteins in the TLR-4 Signaling Cascade. Int J Mol Sci 2020;21(23):8943. doi: 10.3390/ijms21238943
  2. Lötsch J. "Biomedinformatics”: A new journal for the new decade to publish biomedical informatics research. BioMedInformatics 2021 (accepted)
  3. Lötsch J, and Hummel T. Data-science based analysis of patient subgroup structures suggest effects of rhinitis on all chemosensory perceptions in the upper airways. Chem Sens 2021 Jan 1;46:bjab001
  4. Kringel D, Malkusch S, Kalso E, and Lötsch J. Computational functional genomics-based AmpliSeq™ panel for next-generation sequencing of key genes of pain. Int J Mol Sci 2021 Jan 16;22(2):878
  5. Ellinger B, Bojkova D, Zaliani A, Cinatl J, Claussen C, Westhaus S, Keminer O, Reinshagen J, Kuzikov M, Wolf M, Geisslinger G, Gribbon P, Ciesek S. A SARS-CoV-2 cytopathicity dataset generated by high-content screening of a large drug repurposing collection. Sci Data 2021 Feb 26;8(1):70
  6. Rappl P, Rösser S, Maul P, Bauer R, Huard A, Schreiber Y, Thomas D, Geisslinger G, Jakobsson PJ, Weigert A, Brüne B, Schmid T. Inhibition of mPGES-1 attenuates efficient resolution of acute inflammation by enhancing CX3CL1 expression. Cell Death Dis 2021 Feb 2;12(2):135
  7. Nieraad H, de Bruin N, Arne O, Hofmann MCJ, Gurke R, Schmidt D, Ritter M, Parnham MJ, Geisslinger G. Effects of Alzheimer-Like Pathology on Homocysteine and Homocysteic Acid Levels-An Exploratory In Vivo Kinetic Study. Int J Mol Sci 2021 Jan 18;22(2):927
  8. Meyer N, Henkel L, Linder B, Zielke S, Tascher G, Trautmann S, Geisslinger G, Münch C, Fulda S, Tegeder I, Kögel D. Autophagy activation, lipotoxicity and lysosomal membrane permeabilization synergize to promote pimozide- and loperamide-induced glioma cell death. Autophagy 2021 Jan 19:1-20
  9. Blum L, Ulshöfer T, Henke M, Krieg R, Berneburg I, Geisslinger G, Becker K, Parnham MJ, Schiffmann S. The immunomodulatory potential of the arylmethylaminosteroid sc1o. J Mol Med (Berl) 2021 Feb;99(2):261-272. doi: 10.1007/s00109-020-02024-4
  10. Schwalm S, Beyer S, Hafizi R, Trautmann S, Geisslinger G, Adams DR, Pyne S, Pyne N, Schaefer L, Huwiler A, Pfeilschifter J. Validation of highly selective sphingosine kinase 2 inhibitors SLM6031434 and HWG-35D as effective anti-fibrotic treatment options in a mouse model of tubulointerstitial fibrosis. Cell Signal 2021 Mar;79:109881
  11. Lötsch J, Ultsch A, Hähner A, Willgeroth V, Bensafi M, Zaliani A, and Hummel T. Data-science based analysis of perceptual spaces of odors in olfactory loss. Sci Reports 2021 May 19;11(1):10595
  12. Rimola V, Osthues T, Königs V, Geisslinger G, and Sisignano M. Oxaliplatin causes transient changes in TRPM8-channel activity. Int J Mol Sci 2021 May 7;22(9):4962
  13. Fischer C, Wilken-Schmitz A, Hernandez-Olmos V, Proschak E, Stark H, Fleming I, Weigert A, Thurn M, Hofmann M, Werner ER, Geisslinger G, Niederberger E, Watschinger K, and Tegeder I. AGMO Inhibitor Reduces 3T3-L1 Adipogenesis. Cells 2021 May 1;10(5):1081
  14. Hummel R, Lang M, Walderbach S, Wang Y, and Tegeder I, Gölz C, Schäfer MKE. Single intracerebroventricular progranulin injection adversely affects the blood-brain barrier in experimental traumatic brain injury. J Neurochem 2021: doi: 10.1111/jnc.15375
  15. Meyer N, Henkel L, Linder B, Zielke S, Tascher G, Trautmann S, Geisslinger G, Münch C, Fulda S, Tegeder I, and Kögel D. Autophagy activation, lipotoxicity and lysosomal membrane permeabilization synergize to promote pimozide- and loperamide-induced glioma cell death. Autophagy 2021: 1-20; doi: 10.1080/15548627.2021.1874208
  16. Sailer S, Coassin S, Lackner K, Fischer C, McNeill E, Streiter G, Kremser C, Maglione M, Green CM, Moralli D, Moschen AR, Keller MA, Golderer G, Werner-Felmayer G, Tegeder I, Channon KM, Davies B, Werner ER, and Watschinger K. When the genome bluffs: a tandem duplication event during generation of a novel Agmo knockout mouse model fools routine genotyping. Cell Biosci 2021; 11: 54
  17. Schmitz K, Trautmann S, Hahnefeld L, Fischer C, Schreiber Y, Wilken-Schmitz A, Gurke R, Brunkhorst R, Werner ER, Watschinger K, Wicker S, Thomas D, Geisslinger G, and Tegeder I. Sapropterin (BH4) Aggravates Autoimmune Encephalomyelitis in Mice. Neurotherapeutics 2021: doi: 10.1007/s13311-021-01043-4
  18. Tran BN, Valek L, Wilken-Schmitz A, Fuhrmann DC, Namgaladze, Wittig I, and Tegeder I. Reduced exploratory behavior in neuronal nucleoredoxin knockout mice. Redox Biol 2021 Sep;45:102054
  19. Valek L, and Tegeder I. Nucleoredoxin Knockdown in SH-SY5Y Cells Promotes Cell Renewal. Antioxidants (Basel) 2021; 10(3):449. doi: 10.3390/antiox10030449
  20. Valek L, Tran B, Wilken-Schmitz A, Trautmann S, Heidler J, Schmid T, Brüne B, Thomas D, Deller T, Geisslinger G, Auburger G, Tegeder I. Prodromal sensory neuropathy in Pink1(-/-) SNCA(A53T) double mutant Parkinson mice. Neuropathol Appl Neurobiol 2021, doi: 10.1111/nan.12734
  21. Kringel D, Malkusch S, and Lötsch, J. Drugs and epigenetic molecular functions. A pharmacological data scientometric analysis. Int J Mol Sci 2021 Jul 6;22(14):7250
  22. Lötsch J, Malkusch S, and Ultsch A. Optimal distribution-preserving downsampling of large biomedical data sets (opdisDownsampling). PLoS One 2021 Aug 5;16(8):e0255838
  23. Niederberger E, and Parnham MJ. The Impact of Diet and Exercise on Drug Responses. Int J Mol Sci 2021 Jul 19;22(14):7692
  24. Lötsch J, Hintschich CA, Petridis P, Pade J, and Hummel T. Self-ratings of olfactory function and their relation to olfactory test scores. A data science-based analysis in patients with nasal polyposis. Appl Sci 2021 10.3390/app11167279
  25. Malkusch S, Hahnefeld L, Gurke R, and Lötsch J. Visually guided preprocessing of bioanalytical laboratory data using an interactive R notebook (pguIMP). CPT Pharmacometrics Syst Pharmacol 2021 Oct 1. doi: 10.1002/psp4.12704
  26. Sisignano M, Fischer MJM, and Geisslinger G. Proton-sensing GPCRs in health and disease. Cells 2021 Aug 10;10(8):2050
  27. Kraft V, Schmitz K, Wilken-Schmitz A, Geisslinger G, Sisignano M, and Tegeder I. Trehalose reduces nerve injury induced nociception in mice but negatively affects alertness. Nutrients 2021 Aug 25;13(9):2953
  28. Hu J, Brecht R, Sisignano M, Angioni C, Bibli IS, Perumal N, Fisslthaler B, Kleinert H, Pfeiffer N, Fleming I, and Manicam C. Proton-sensing GPCRs in health and disease. Scientific Reports Sci Rep 2021 Sep 21;11(1):18764
  29. Lötsch J, Hähner A, Schwarz PEH, Tselmin S, and Hummel T. Machine-learning points at endoscopic, life-quality and olfactory parameters as outcome criteria for endoscopic paranasal sinus surgery in chronic rhinosinusitis . J Clin Med 2021 Sep 18;10(18):4245
  30. Lötsch J, Hintschich CA, Petridis P, Pade J, and Hummel T. Machine learning refutes loss of smell as a risk indicator of diabetes mellitus. J Clin Med 2021 (accepted)
  31. Rahm JV, Malkusch S, Endesfelder U, Dietz MS, and Heilemann M. Diffusion State Transitions in Single-Particle Trajectories of MET Receptor Tyrosine Kinase Measured in Live Cells. Front Comput Sci 2021 12 November https://doi.org/10.3389/fcomp.2021.757653
  32. Dinh TS, González-González AI, Meid AD, Snell KIE, Rudolf H, Brueckle MS, Blom JW, Thiem U, Trampisch HJ, Elders PJM, Donner-Banzhoff N, Gerlach FM, Harder S, van den Akker M, Glasziou PP, Haefeli WE, Muth C. Are Anticholinergic Symptoms a Risk Factor for Falls in Older General Practice Patients With Polypharmacy? Study Protocol for the Development and Validation of a Prognostic Model. Front Pharmacol 2021 Jan 14;11:577747
  33. Kann G, Owasil J, Kuczka K, Haberl A, Wolf T, Khaykin P, Harder S, Stephan C, von Hentig N. Evaluation of Platelet Activation by HIV Protease Inhibitors - The HIV-PLA II Study. HIV AIDS (Auckl) 2021 Aug 6;13:789-800
  34. Müller BS, Klaaßen-Mielke R, Gonzalez-Gonzalez AI, Grandt D, Hammerschmidt R, Köberlein-Neu J, Kellermann-Mühlhoff P, Trampisch HJ, Beckmann T, Düvel L, Surmann B, Flaig B, Ihle P, Söling S, Grandt S, Dinh TS, Piotrowski A, Meyer I, Karbach U, Harder S, Perera R, Glasziou P, Pfaff H, Greiner W, Gerlach FM, Timmesfeld N, Muth C; AdAM study group. Effectiveness of the application of an electronic medication management support system in patients with polypharmacy in general practice: a study protocol of cluster-randomised controlled trial (AdAM). BMJ Open 2021 Sep 28;11(9):e048191